psoriatic arthritis: Joint inflammation associated with psoriasis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
811 |
4. Check minimum number of eventsNone |
811 |
5. Include endpointsNone |
811 |
6. Filter based on genotype QC (FinnGen only) |
776 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Enteropathic arthropathies
based on the number of shared cases.
Similar with more cases:
- Psoriatic and enteropathic arthropathies
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3845 | 2119 | 1711 |
| Only index persons | 3646 | 2038 | 1608 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 44.81 | 45.37 | 44.02 |
| Only index persons | 44.26 | 44.98 | 43.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 776 | 480 | 296 |
| Unadjusted period prevalence (%) | 0.17 | 0.19 | 0.15 |
| Median age at first event (years) | 44.91 | 43.59 | 47.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ENTEROARTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ENTEROARTHR | 1.395 [1.15, 1.69] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.455 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 1603 females with M13_ENTEROARTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ENTEROARTHR | 1.313 [1.08, 1.59] | 0.006 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 154 out of 1230 males with M13_ENTEROARTHR died.
Mortality risk
Mortality risk for people of age
years, who have M13_ENTEROARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.23% |
| 5 | 0.878% | 1.55% |
| 10 | 2.166% | 3.741% |
| 15 | 4.3% | 6.91% |
| 20 | 7.2% | 11.991% |
Relationships between endpoints
↥Index endpoint: M13_ENTEROARTHR – Enteropathic arthropathies
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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