Enteropathic arthropathies

M13_ENTEROARTHR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

811

4. Check minimum number of events

None

811

5. Include endpoints

None

811

6. Filter based on genotype QC (FinnGen only)

776

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3845 2119 1711
Only index persons 3646 2038 1608
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.05
Only index persons 0.07 0.07 0.06
Median age at first event (years)
Whole population 44.81 45.37 44.02
Only index persons 44.26 44.98 43.36

-FinnGen-

Key figures

All Female Male
Number of individuals 776 480 296
Unadjusted period prevalence (%) 0.17 0.19 0.15
Median age at first event (years) 44.91 43.59 47.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_ENTEROARTHR and mortality.

Females

Parameter HR [95% CI] p-value
M13_ENTEROARTHR 1.395 [1.15, 1.69] < 0.001
Birth year 0.997 [0.99, 1.01] 0.455

During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 1603 females with M13_ENTEROARTHR died.

Males

Parameter HR [95% CI] p-value
M13_ENTEROARTHR 1.313 [1.08, 1.59] 0.006
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 154 out of 1230 males with M13_ENTEROARTHR died.

Mortality risk

Mortality risk for people of age

years, who have M13_ENTEROARTHR.

N-year risk Females Males
1 0.16% 0.23%
5 0.878% 1.55%
10 2.166% 3.741%
15 4.3% 6.91%
20 7.2% 11.991%

Relationships between endpoints

Index endpoint: M13_ENTEROARTHR – Enteropathic arthropathies

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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