psoriatic arthritis: Joint inflammation associated with psoriasis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
423 |
4. Check minimum number of eventsNone |
423 |
5. Include endpointsNone |
423 |
6. Filter based on genotype QC (FinnGen only) |
403 |
Control definitions (FinnGen only)
Control exclude
PSOR_ENTE_ARTHR
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Arthropathy in ulcerative colitis
based on the number of shared cases.
Similar with more cases:
- Enteropathic arthropathies
- Psoriatic and enteropathic arthropathies
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1853 | 1058 | 791 |
| Only index persons | 1802 | 1037 | 765 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 45.60 | 44.83 | 46.65 |
| Only index persons | 45.25 | 44.58 | 46.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 403 | 262 | 141 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 46.66 | 44.98 | 49.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ULCER_ARTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCER_ARTHR | 1.403 [1.1, 1.79] | 0.006 |
| Birth year | 0.996 [0.99, 1.0] | 0.305 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 907 females with ULCER_ARTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCER_ARTHR | 1.167 [0.92, 1.49] | 0.212 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 698 males with ULCER_ARTHR died.
Mortality risk
Mortality risk for people of age
years, who have ULCER_ARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.177% |
| 5 | 0.763% | 1.472% |
| 10 | 1.952% | 3.667% |
| 15 | 3.853% | 7.007% |
| 20 | 6.948% | 12.123% |
Relationships between endpoints
↥Index endpoint: ULCER_ARTHR – Arthropathy in ulcerative colitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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