psoriatic arthritis: Joint inflammation associated with psoriasis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
337 |
4. Check minimum number of eventsNone |
337 |
5. Include endpointsNone |
337 |
6. Filter based on genotype QC (FinnGen only) |
325 |
Control definitions (FinnGen only)
Control exclude
PSOR_ENTE_ARTHR
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Arthropathy in Crohn disease
based on the number of shared cases.
Similar with more cases:
- Enteropathic arthropathies
- Psoriatic and enteropathic arthropathies
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1448 | 820 | 623 |
| Only index persons | 1391 | 801 | 590 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.47 | 45.71 | 45.14 |
| Only index persons | 45.12 | 45.60 | 44.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 325 | 203 | 122 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 44.28 | 43.65 | 45.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CROHN_ARTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CROHN_ARTHR | 1.408 [1.06, 1.87] | 0.018 |
| Birth year | 0.991 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 730 females with CROHN_ARTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CROHN_ARTHR | 1.394 [1.06, 1.83] | 0.018 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 562 males with CROHN_ARTHR died.
Mortality risk
Mortality risk for people of age
years, who have CROHN_ARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.215% |
| 5 | 0.773% | 1.587% |
| 10 | 1.813% | 3.786% |
| 15 | 3.506% | 7.126% |
| 20 | 5.89% | 11.945% |
Relationships between endpoints
↥Index endpoint: CROHN_ARTHR – Arthropathy in Crohn disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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