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Reactive arthropathies

DOID EFO Endpoint Browser PheWeb

M13_REACTARTH

reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M02, M03*
  • Hospital discharge: ICD-9 — 7111|7115|7118|713
  • Hospital discharge: ICD-8 — 71490
  • Cause of death: ICD-10 — M02, M03*
  • Cause of death: ICD-9 — 7111|7115|7118|713
  • Cause of death: ICD-8 — 71490

2 out of 7 registries used, show all original rules.

3489

4. Check minimum number of events

None

3489

5. Include endpoints

None

3489

6. Filter based on genotype QC (FinnGen only)

3384

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28731 13789 14752
Only index persons 25824 12637 13187
Unadjusted period prevalence (%)
Whole population 0.40 0.39 0.41
Only index persons 0.48 0.46 0.50
Median age at first event (years)
Whole population 41.97 43.22 40.67
Only index persons 40.95 42.21 39.74

-FinnGen-

Key figures

All Female Male
Number of individuals 3384 1864 1520
Unadjusted period prevalence (%) 0.75 0.73 0.76
Median age at first event (years) 43.67 41.98 45.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_REACTARTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_REACTARTH 1.224 [1.1, 1.37] < 0.001
Birth year 0.994 [0.99, 1.0] 0.135

During the follow-up period (1.1.1998 — 31.12.2019), 1005 out of 9191 females with M13_REACTARTH died.

Males

Parameter HR [95% CI] p-value
M13_REACTARTH 1.254 [1.13, 1.39] < 0.001
Birth year 0.99 [0.98, 1.0] 0.031

During the follow-up period (1.1.1998 — 31.12.2019), 1365 out of 9460 males with M13_REACTARTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_REACTARTH.

N-year risk Females Males
1 0.138% 0.251%
5 0.681% 1.546%
10 1.727% 4.137%
15 3.457% 7.852%
20 5.882% 13.56%

Relationships between endpoints

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Index endpoint: M13_REACTARTH – Reactive arthropathies

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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