reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
317 |
4. Check minimum number of eventsNone |
317 |
5. Include endpointsNone |
317 |
6. Filter based on genotype QC (FinnGen only) |
311 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ARHTROPAT_REACTIVE
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M02
Name in latin
Arthropathia post infectionem intestinalem
Similar endpoints
↥List of similar endpoints to
Postdysenteric arthropathy
based on the number of shared cases.
Similar with more cases:
- Reactive arthropathies, FINNGEN
- Reactive arthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2221 | 1079 | 1138 |
| Only index persons | 2145 | 1048 | 1097 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 45.19 | 45.69 | 44.72 |
| Only index persons | 44.97 | 45.57 | 44.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 311 | 170 | 141 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | 46.92 | 46.34 | 47.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ARTRHO_POSTDYSENTERIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTRHO_POSTDYSENTERIC | 1.182 [0.9, 1.55] | 0.228 |
| Birth year | 0.999 [0.99, 1.01] | 0.765 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 974 females with ARTRHO_POSTDYSENTERIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTRHO_POSTDYSENTERIC | 0.814 [0.65, 1.02] | 0.071 |
| Birth year | 0.986 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 1010 males with ARTRHO_POSTDYSENTERIC died.
Mortality risk
Mortality risk for people of age
years, who have ARTRHO_POSTDYSENTERIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.138% |
| 5 | 0.787% | 0.85% |
| 10 | 1.998% | 2.199% |
| 15 | 3.78% | 4.239% |
| 20 | 6.482% | 7.309% |
Relationships between endpoints
↥Index endpoint: ARTRHO_POSTDYSENTERIC – Postdysenteric arthropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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