reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2702 |
6. Filter based on genotype QC (FinnGen only) |
2615 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Reactive arthropathies, FINNGEN
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21080 | 10192 | 10784 |
| Only index persons | 19480 | 9565 | 9915 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.30 | 0.29 | 0.30 |
| Only index persons | 0.37 | 0.35 | 0.38 |
| Median age at first event (years) | |||
| Whole population | 44.48 | 45.08 | 43.82 |
| Only index persons | 43.96 | 44.60 | 43.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2615 | 1474 | 1141 |
| Unadjusted period prevalence (%) | 0.58 | 0.58 | 0.57 |
| Median age at first event (years) | 46.58 | 44.28 | 49.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_ARHTROPAT_REACTIVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_ARHTROPAT_REACTIVE | 1.218 [1.09, 1.37] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.272 |
During the follow-up period (1.1.1998 — 31.12.2019), 938 out of 8775 females with RHEUMA_ARHTROPAT_REACTIVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_ARHTROPAT_REACTIVE | 1.248 [1.12, 1.39] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1291 out of 9100 males with RHEUMA_ARHTROPAT_REACTIVE died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_ARHTROPAT_REACTIVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.27% |
| 5 | 0.792% | 1.373% |
| 10 | 2.003% | 3.698% |
| 15 | 3.651% | 6.94% |
| 20 | 6.399% | 11.844% |
Relationships between endpoints
↥Index endpoint: RHEUMA_ARHTROPAT_REACTIVE – Reactive arthropathies, FINNGEN
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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