reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
202 |
4. Check minimum number of eventsNone |
202 |
5. Include endpointsNone |
202 |
6. Filter based on genotype QC (FinnGen only) |
197 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ARHTROPAT_REACTIVE
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M02
Name in latin
Morbus Reiter
Similar endpoints
↥List of similar endpoints to
Reiter disease
based on the number of shared cases.
Similar with more cases:
- Reactive arthropathies, FINNGEN
- Finngen Rheumatological endpoints
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1810 | 445 | 1350 |
| Only index persons | 1625 | 422 | 1203 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.01 | 0.04 |
| Only index persons | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 43.46 | 44.10 | 43.14 |
| Only index persons | 42.52 | 43.47 | 42.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 197 | 65 | 132 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.07 |
| Median age at first event (years) | 42.64 | 38.01 | 44.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint REITER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| REITER | 1.516 [1.12, 2.06] | 0.008 |
| Birth year | 0.999 [0.99, 1.01] | 0.892 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 387 females with REITER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| REITER | 1.526 [1.28, 1.82] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 1071 males with REITER died.
Mortality risk
Mortality risk for people of age
years, who have REITER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.168% | 0.209% |
| 5 | 1.11% | 1.463% |
| 10 | 2.728% | 3.843% |
| 15 | 5.054% | 7.025% |
| 20 | 9.186% | 12.038% |
Relationships between endpoints
↥Index endpoint: REITER – Reiter disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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