No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7897 |
4. Check minimum number of eventsNone |
7897 |
5. Include endpointsNone |
7897 |
6. Filter based on genotype QC (FinnGen only) |
7652 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of patella
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 57673 | 32560 | 24951 |
| Only index persons | 55938 | 31855 | 24083 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.83 | 0.93 | 0.70 |
| Only index persons | 1.06 | 1.17 | 0.92 |
| Median age at first event (years) | |||
| Whole population | 34.94 | 35.33 | 34.43 |
| Only index persons | 34.78 | 35.22 | 34.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7652 | 5096 | 2556 |
| Unadjusted period prevalence (%) | 1.76 | 2.00 | 1.28 |
| Median age at first event (years) | 37.33 | 36.77 | 38.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_PATELLAOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PATELLAOTH | 0.832 [0.73, 0.94] | 0.004 |
| Birth year | 0.994 [0.98, 1.0] | 0.261 |
During the follow-up period (1.1.1998 — 31.12.2019), 595 out of 22235 females with M13_PATELLAOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PATELLAOTH | 0.733 [0.66, 0.81] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 744 out of 15618 males with M13_PATELLAOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_PATELLAOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.153% |
| 5 | 0.507% | 0.853% |
| 10 | 1.232% | 2.22% |
| 15 | 2.22% | 4.267% |
| 20 | 3.907% | 7.256% |
Relationships between endpoints
↥Index endpoint: M13_PATELLAOTH – Other disorders of patella
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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