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Contracture of joint

EFO MESH Endpoint Browser PheWeb

M13_CONTRACTUREJOINT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M24.5
  • Hospital discharge: ICD-9 — 7184
  • Hospital discharge: ICD-8 — 72900
  • Cause of death: ICD-10 — M24.5
  • Cause of death: ICD-9 — 7184
  • Cause of death: ICD-8 — 72900

2 out of 7 registries used, show all original rules.

423

4. Check minimum number of events

None

423

5. Include endpoints

None

423

6. Filter based on genotype QC (FinnGen only)

403

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M24
Name in latin Contractura articulationis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4443 2087 2306
Only index persons 3699 1819 1880
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 50.49 51.25 49.64
Only index persons 48.48 50.18 46.83

-FinnGen-

Key figures

All Female Male
Number of individuals 403 212 191
Unadjusted period prevalence (%) 0.09 0.08 0.10
Median age at first event (years) 49.46 47.04 52.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_CONTRACTUREJOINT and mortality.

Females

Parameter HR [95% CI] p-value
M13_CONTRACTUREJOINT 1.246 [1.0, 1.56] 0.055
Birth year 0.997 [0.99, 1.01] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 1054 females with M13_CONTRACTUREJOINT died.

Males

Parameter HR [95% CI] p-value
M13_CONTRACTUREJOINT 1.31 [1.07, 1.6] 0.009
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1179 males with M13_CONTRACTUREJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_CONTRACTUREJOINT.

N-year risk Females Males
1 0.124% 0.248%
5 0.842% 1.646%
10 1.817% 4.002%
15 3.492% 7.282%
20 6.293% 11.894%

Relationships between endpoints

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Index endpoint: M13_CONTRACTUREJOINT – Contracture of joint

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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