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Other deformities of toe(s)

EFO MESH Endpoint Browser PheWeb

M13_TOEDEFORMOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M20.5, M20.6
  • Hospital discharge: ICD-9 — 735[8-9]
  • Cause of death: ICD-10 — M20.5, M20.6
  • Cause of death: ICD-9 — 735[8-9]

2 out of 7 registries used, show all original rules.

1212

4. Check minimum number of events

None

1212

5. Include endpoints

None

1212

6. Filter based on genotype QC (FinnGen only)

1172

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8220 6036 2146
Only index persons 7684 5724 1960
Unadjusted period prevalence (%)
Whole population 0.14 0.17 0.06
Only index persons 0.18 0.21 0.07
Median age at first event (years)
Whole population 55.11 55.37 54.28
Only index persons 54.47 54.78 53.58

-FinnGen-

Key figures

All Female Male
Number of individuals 1172 891 281
Unadjusted period prevalence (%) 0.30 0.35 0.14
Median age at first event (years) 55.77 55.20 57.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_TOEDEFORMOTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_TOEDEFORMOTH 0.927 [0.82, 1.05] 0.218
Birth year 0.994 [0.99, 1.0] 0.201

During the follow-up period (1.1.1998 — 31.12.2019), 452 out of 3987 females with M13_TOEDEFORMOTH died.

Males

Parameter HR [95% CI] p-value
M13_TOEDEFORMOTH 1.03 [0.88, 1.21] 0.72
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 1474 males with M13_TOEDEFORMOTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_TOEDEFORMOTH.

N-year risk Females Males
1 0.079% 0.15%
5 0.548% 1.001%
10 1.352% 2.461%
15 2.691% 4.761%
20 4.628% 8.131%

Relationships between endpoints

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Index endpoint: M13_TOEDEFORMOTH – Other deformities of toe(s)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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