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Other articular cartilage disorders

DOID EFO Endpoint Browser PheWeb

M13_CARTILAGE

cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M24.1
  • Hospital discharge: ICD-9 — 7180
  • Hospital discharge: ICD-8 — 7249
  • Cause of death: ICD-10 — M24.1
  • Cause of death: ICD-9 — 7180
  • Cause of death: ICD-8 — 7249

2 out of 7 registries used, show all original rules.

869

4. Check minimum number of events

None

869

5. Include endpoints

None

869

6. Filter based on genotype QC (FinnGen only)

850

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M24
Name in latin Alia vitia cartilaginum articularium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7026 3215 3754
Only index persons 6071 2847 3224
Unadjusted period prevalence (%)
Whole population 0.10 0.09 0.10
Only index persons 0.11 0.10 0.12
Median age at first event (years)
Whole population 37.19 39.65 34.93
Only index persons 35.55 37.92 33.46

-FinnGen-

Key figures

All Female Male
Number of individuals 850 419 431
Unadjusted period prevalence (%) 0.19 0.16 0.22
Median age at first event (years) 35.31 34.62 35.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_CARTILAGE and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
M13_CARTILAGE 1.362 [1.0, 1.85] 0.05
Birth year 0.98 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 796 males with M13_CARTILAGE died.

Mortality risk

Mortality risk for people of age

years, who have M13_CARTILAGE.

N-year risk Females Males
1 No data 0.249%
5 No data 1.259%
10 No data 3.205%
15 No data 5.826%
20 No data 9.971%

Relationships between endpoints

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Index endpoint: M13_CARTILAGE – Other articular cartilage disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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