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Flat foot [pes planus] (acquired)

EFO MESH Endpoint Browser PheWeb

M13_FLATFOOT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M21.4
  • Hospital discharge: ICD-9 — 734
  • Hospital discharge: ICD-8 — 736
  • Cause of death: ICD-10 — M21.4
  • Cause of death: ICD-9 — 734
  • Cause of death: ICD-8 — 736

2 out of 7 registries used, show all original rules.

3513

4. Check minimum number of events

None

3513

5. Include endpoints

None

3513

6. Filter based on genotype QC (FinnGen only)

3419

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M21
Name in latin Pes planus [acquisitus]

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 25519 17496 7934
Only index persons 24438 16888 7550
Unadjusted period prevalence (%)
Whole population 0.41 0.50 0.22
Only index persons 0.52 0.62 0.29
Median age at first event (years)
Whole population 51.28 56.75 39.24
Only index persons 51.66 56.72 40.34

-FinnGen-

Key figures

All Female Male
Number of individuals 3419 2613 806
Unadjusted period prevalence (%) 0.88 1.03 0.40
Median age at first event (years) 56.66 56.74 56.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_FLATFOOT and mortality.

Females

Parameter HR [95% CI] p-value
M13_FLATFOOT 0.849 [0.75, 0.96] 0.012
Birth year 0.999 [0.99, 1.01] 0.808

During the follow-up period (1.1.1998 — 31.12.2019), 893 out of 13803 females with M13_FLATFOOT died.

Males

Parameter HR [95% CI] p-value
M13_FLATFOOT 0.893 [0.76, 1.04] 0.158
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 6077 males with M13_FLATFOOT died.

Mortality risk

Mortality risk for people of age

years, who have M13_FLATFOOT.

N-year risk Females Males
1 0.074% 0.185%
5 0.496% 1.028%
10 1.258% 2.671%
15 2.643% 5.04%
20 5.024% 8.603%

Relationships between endpoints

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Index endpoint: M13_FLATFOOT – Flat foot [pes planus] (acquired)

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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