Valgus deformity, not elsewhere classified

M13_VALGUS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M21.0
  • Hospital discharge: ICD-9 7360A|7363A|7364A
  • Hospital discharge: ICD-8 73802|73800
  • Cause of death: ICD-10 M21.0
  • Cause of death: ICD-9 7360A|7363A|7364A
  • Cause of death: ICD-8 73802|73800

2 out of 7 registries used, show all original rules.

255

4. Check minimum number of events

None

255

5. Include endpoints

None

255

6. Filter based on genotype QC (FinnGen only)

249

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M21
Name in latin Deformitas membri valga non alibi classificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2937 1838 1089
Only index persons 2579 1613 966
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 35.31 47.23 14.96
Only index persons 34.02 45.33 15.13

-FinnGen-

Key figures

All Female Male
Number of individuals 249 175 74
Unadjusted period prevalence (%) 0.06 0.07 0.04
Median age at first event (years) 39.78 45.50 26.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint M13_VALGUS and mortality.

Females

Parameter HR [95% CI] p-value
M13_VALGUS 0.979 [0.79, 1.21] 0.846
Birth year 0.994 [0.99, 1.0] 0.186

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 1234 females with M13_VALGUS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_VALGUS.

N-year risk Females Males
1 0.108% No data
5 0.609% No data
10 1.436% No data
15 2.867% No data
20 4.812% No data

Relationships between endpoints

Index endpoint: M13_VALGUS – Valgus deformity, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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