No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
152 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Other specified acquired deformities of limbs
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1624 | 978 | 639 |
| Only index persons | 1493 | 897 | 596 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 32.12 | 39.17 | 21.06 |
| Only index persons | 31.42 | 38.34 | 21.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 152 | 102 | 50 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 40.03 | 39.27 | 41.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_LIMBDEFORM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LIMBDEFORM | 1.57 [1.14, 2.17] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 621 females with M13_LIMBDEFORM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_LIMBDEFORM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | No data |
| 5 | 0.894% | No data |
| 10 | 2.358% | No data |
| 15 | 4.271% | No data |
| 20 | 7.636% | No data |
Relationships between endpoints
↥Index endpoint: M13_LIMBDEFORM – Other specified acquired deformities of limbs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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