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Loose body in joint

EFO MESH Endpoint Browser PheWeb

M13_LOOSEJOINT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M24.0
  • Hospital discharge: ICD-9 — 7181
  • Hospital discharge: ICD-8 — 72901
  • Cause of death: ICD-10 — M24.0
  • Cause of death: ICD-9 — 7181
  • Cause of death: ICD-8 — 72901

2 out of 7 registries used, show all original rules.

835

4. Check minimum number of events

None

835

5. Include endpoints

None

835

6. Filter based on genotype QC (FinnGen only)

816

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M24
Name in latin Corpus liberum articulationis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7793 2490 5243
Only index persons 6900 2215 4685
Unadjusted period prevalence (%)
Whole population 0.12 0.07 0.15
Only index persons 0.15 0.08 0.18
Median age at first event (years)
Whole population 39.44 43.27 37.54
Only index persons 37.78 41.19 36.17

-FinnGen-

Key figures

All Female Male
Number of individuals 816 288 528
Unadjusted period prevalence (%) 0.21 0.11 0.27
Median age at first event (years) 39.18 38.59 39.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_LOOSEJOINT and mortality.

Females

Parameter HR [95% CI] p-value
M13_LOOSEJOINT 0.759 [0.58, 0.99] 0.038
Birth year 0.999 [0.99, 1.01] 0.773

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1209 females with M13_LOOSEJOINT died.

Males

Parameter HR [95% CI] p-value
M13_LOOSEJOINT 0.783 [0.66, 0.94] 0.007
Birth year 0.985 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 2346 males with M13_LOOSEJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_LOOSEJOINT.

N-year risk Females Males
1 0.081% 0.149%
5 0.524% 0.934%
10 1.311% 2.189%
15 2.421% 4.269%
20 4.278% 7.068%

Relationships between endpoints

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Index endpoint: M13_LOOSEJOINT – Loose body in joint

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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