No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
29716 |
4. Check minimum number of eventsNone |
29716 |
5. Include endpointsNone |
29716 |
6. Filter based on genotype QC (FinnGen only) |
28818 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Meniscus derangement
based on the number of shared cases.
Similar with more cases:
- Internal derangement of knee
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 229998 | 104782 | 124485 |
| Only index persons | 220228 | 101352 | 118876 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.25 | 3.00 | 3.48 |
| Only index persons | 4.16 | 3.73 | 4.54 |
| Median age at first event (years) | |||
| Whole population | 50.45 | 53.56 | 47.84 |
| Only index persons | 50.21 | 53.35 | 47.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 28818 | 14444 | 14374 |
| Unadjusted period prevalence (%) | 6.44 | 5.67 | 7.22 |
| Median age at first event (years) | 51.30 | 52.18 | 50.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_MENISCUSDERANGEMENTS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MENISCUSDERANGEMENTS | 0.69 [0.64, 0.74] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.291 |
During the follow-up period (1.1.1998 — 31.12.2019), 7176 out of 82957 females with M13_MENISCUSDERANGEMENTS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MENISCUSDERANGEMENTS | 0.666 [0.62, 0.72] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 8743 out of 93194 males with M13_MENISCUSDERANGEMENTS died.
Mortality risk
Mortality risk for people of age
years, who have M13_MENISCUSDERANGEMENTS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | 0.136% |
| 5 | 0.436% | 0.74% |
| 10 | 1.049% | 1.943% |
| 15 | 2.079% | 3.782% |
| 20 | 3.595% | 6.682% |
Relationships between endpoints
↥Index endpoint: M13_MENISCUSDERANGEMENTS – Meniscus derangement
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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