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Hallux rigidus

EFO MESH Endpoint Browser PheWeb

M13_HALLUXRIGIDUS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M20.2
  • Hospital discharge: ICD-9 — 7352
  • Hospital discharge: ICD-8 — 73804
  • Cause of death: ICD-10 — M20.2
  • Cause of death: ICD-9 — 7352
  • Cause of death: ICD-8 — 73804

2 out of 7 registries used, show all original rules.

5495

4. Check minimum number of events

None

5495

5. Include endpoints

None

5495

6. Filter based on genotype QC (FinnGen only)

5321

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M20
Name in latin Hallux rigidus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34570 21524 12869
Only index persons 32120 20474 11646
Unadjusted period prevalence (%)
Whole population 0.52 0.62 0.36
Only index persons 0.64 0.75 0.44
Median age at first event (years)
Whole population 56.77 57.08 56.21
Only index persons 56.58 56.96 55.92

-FinnGen-

Key figures

All Female Male
Number of individuals 5321 3465 1856
Unadjusted period prevalence (%) 1.21 1.36 0.93
Median age at first event (years) 56.93 56.85 57.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_HALLUXRIGIDUS and mortality.

Females

Parameter HR [95% CI] p-value
M13_HALLUXRIGIDUS 0.692 [0.63, 0.77] < 0.001
Birth year 0.996 [0.99, 1.0] 0.295

During the follow-up period (1.1.1998 — 31.12.2019), 1235 out of 15569 females with M13_HALLUXRIGIDUS died.

Males

Parameter HR [95% CI] p-value
M13_HALLUXRIGIDUS 0.711 [0.65, 0.78] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1175 out of 8767 males with M13_HALLUXRIGIDUS died.

Mortality risk

Mortality risk for people of age

years, who have M13_HALLUXRIGIDUS.

N-year risk Females Males
1 0.091% 0.143%
5 0.529% 0.784%
10 1.199% 1.903%
15 2.218% 3.727%
20 3.866% 6.778%

Relationships between endpoints

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Index endpoint: M13_HALLUXRIGIDUS – Hallux rigidus

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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