skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Other disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_OTHERSKINSUBCUTIS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
30384 |
4. Check minimum number of eventsNone |
30384 |
5. Include endpoints
|
31807 |
6. Filter based on genotype QC (FinnGen only) |
30692 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 255760 | 152809 | 101212 |
| Only index persons | 223030 | 135571 | 87459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.75 | 4.38 | 2.83 |
| Only index persons | 4.34 | 4.98 | 3.34 |
| Median age at first event (years) | |||
| Whole population | 61.68 | 62.52 | 60.40 |
| Only index persons | 60.52 | 61.10 | 59.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 30692 | 18664 | 12028 |
| Unadjusted period prevalence (%) | 6.82 | 7.33 | 6.04 |
| Median age at first event (years) | 60.78 | 58.59 | 64.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERSKINSUBCUTIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERSKINSUBCUTIS | 1.619 [1.48, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 28500 out of 110905 females with L12_OTHERSKINSUBCUTIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERSKINSUBCUTIS | 2.076 [1.86, 2.31] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 23014 out of 73948 males with L12_OTHERSKINSUBCUTIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERSKINSUBCUTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.341% |
| 5 | 0.676% | 1.923% |
| 10 | 1.905% | 4.86% |
| 15 | 3.866% | 8.64% |
| 20 | 6.636% | 14.346% |
Relationships between endpoints
↥Index endpoint: L12_OTHERSKINSUBCUTIS – Other disorders of skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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