skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Other disorders of skin and subcutaneous tissue, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
L12_OTHERDISSKINANDSUBCUTIS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4968 |
4. Check minimum number of eventsNone |
4968 |
5. Include endpoints |
5456 |
6. Filter based on genotype QC (FinnGen only) |
5282 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Aliae morbositates cutis et telae subcutaneae non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Other disorders of skin and subcutaneous tissue, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 46108 | 25848 | 19852 |
| Only index persons | 37465 | 21163 | 16302 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.66 | 0.74 | 0.55 |
| Only index persons | 0.71 | 0.78 | 0.62 |
| Median age at first event (years) | |||
| Whole population | 60.72 | 62.25 | 58.73 |
| Only index persons | 58.99 | 59.85 | 57.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5282 | 2956 | 2326 |
| Unadjusted period prevalence (%) | 1.16 | 1.16 | 1.17 |
| Median age at first event (years) | 58.53 | 55.48 | 62.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERDISSKINANDSUBCUTIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERDISSKINANDSUBCUTIS | 2.196 [1.99, 2.42] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.333 |
During the follow-up period (1.1.1998 — 31.12.2019), 6435 out of 18440 females with L12_OTHERDISSKINANDSUBCUTIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERDISSKINANDSUBCUTIS | 2.452 [2.19, 2.74] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5114 out of 14312 males with L12_OTHERDISSKINANDSUBCUTIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERDISSKINANDSUBCUTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.244% | 0.341% |
| 5 | 1.285% | 2.097% |
| 10 | 3.011% | 5.776% |
| 15 | 6.093% | 10.843% |
| 20 | 11.44% | 17.781% |
Relationships between endpoints
↥Index endpoint: L12_OTHERDISSKINANDSUBCUTIS – Other disorders of skin and subcutaneous tissue, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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