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Other and unspecified disorders of skin and subcutaneous tissue

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L12_SKINSUBCUTISNAS

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L98.80, L98.88, L98.9
  • Hospital discharge: ICD-9 — 7019X|7098|7099
  • Hospital discharge: ICD-8 — 70198|7090[8-9]
  • Hospital discharge: excluded ICD-9 — 7098A|7098B
  • Cause of death: ICD-10 — L98.80, L98.88, L98.9
  • Cause of death: ICD-9 — 7019X|7098|7099
  • Cause of death: ICD-8 — 70198|7090[8-9]
  • Cause of death: excluded ICD-9 — 7098A|7098B

2 out of 7 registries used, show all original rules.

2337

4. Check minimum number of events

None

2337

5. Include endpoints

None

2337

6. Filter based on genotype QC (FinnGen only)

2258

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14996 8917 5967
Only index persons 12956 7849 5107
Unadjusted period prevalence (%)
Whole population 0.22 0.26 0.17
Only index persons 0.25 0.29 0.19
Median age at first event (years)
Whole population 51.34 52.02 50.23
Only index persons 49.71 50.36 48.71

-FinnGen-

Key figures

All Female Male
Number of individuals 2258 1426 832
Unadjusted period prevalence (%) 0.51 0.56 0.42
Median age at first event (years) 54.37 52.25 58.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_SKINSUBCUTISNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_SKINSUBCUTISNAS 1.368 [1.23, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.191

During the follow-up period (1.1.1998 — 31.12.2019), 1166 out of 6189 females with L12_SKINSUBCUTISNAS died.

Males

Parameter HR [95% CI] p-value
L12_SKINSUBCUTISNAS 1.462 [1.29, 1.65] < 0.001
Birth year 0.99 [0.98, 1.0] 0.025

During the follow-up period (1.1.1998 — 31.12.2019), 1088 out of 4258 males with L12_SKINSUBCUTISNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_SKINSUBCUTISNAS.

N-year risk Females Males
1 0.116% 0.266%
5 0.766% 1.559%
10 1.775% 4.387%
15 3.456% 8.53%
20 6.376% 14.554%

Relationships between endpoints

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Index endpoint: L12_SKINSUBCUTISNAS – Other and unspecified disorders of skin and subcutaneous tissue

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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