skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Other infiltrative disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_OTHERINFILTRATIVESKIN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
154 |
4. Check minimum number of eventsNone |
154 |
5. Include endpointsNone |
154 |
6. Filter based on genotype QC (FinnGen only) |
150 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L98
Name in latin
Aliae morbositates infiltrativae cutis et textus subcutanei
Similar endpoints
↥List of similar endpoints to
Other infiltrative disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1124 | 634 | 485 |
| Only index persons | 1034 | 597 | 437 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.18 | 56.99 | 52.63 |
| Only index persons | 55.43 | 57.00 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 150 | 93 | 57 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | 55.55 | 53.99 | 58.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERINFILTRATIVESKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERINFILTRATIVESKIN | 1.16 [0.89, 1.5] | 0.264 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 583 females with L12_OTHERINFILTRATIVESKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERINFILTRATIVESKIN | 1.305 [0.99, 1.71] | 0.055 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 442 males with L12_OTHERINFILTRATIVESKIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERINFILTRATIVESKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.224% |
| 5 | 0.767% | 1.307% |
| 10 | 1.624% | 3.239% |
| 15 | 3.128% | 6.275% |
| 20 | 5.646% | 10.793% |
Relationships between endpoints
↥Index endpoint: L12_OTHERINFILTRATIVESKIN – Other infiltrative disorders of skin and subcutaneous tissue
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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