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Chronic ulcer of skin, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

L12_CHRONICULCEROFSKIN

chronic ulcer of skin: ['Chronic skin ulceration is a common complication of diabetes, peripheral vascular disease, and disorders that decrease mobility. Local ulcer care will be successful only if the underlying cause is correctly identified and steps are taken to reverse it.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L98.4
  • Hospital discharge: ICD-9 — 707[8-9]
  • Hospital discharge: ICD-8 — 707
  • Hospital discharge: excluded ICD-8 — 70700
  • Cause of death: ICD-10 — L98.4
  • Cause of death: ICD-9 — 707[8-9]
  • Cause of death: ICD-8 — 707
  • Cause of death: excluded ICD-8 — 70700

2 out of 7 registries used, show all original rules.

2307

4. Check minimum number of events

None

2307

5. Include endpoints

None

2307

6. Filter based on genotype QC (FinnGen only)

2242

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L98
Name in latin Ulcus chronicum cutis non alibi classificatum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24012 13020 10742
Only index persons 18158 9740 8418
Unadjusted period prevalence (%)
Whole population 0.34 0.37 0.30
Only index persons 0.34 0.36 0.32
Median age at first event (years)
Whole population 68.83 72.35 64.68
Only index persons 68.70 72.24 64.60

-FinnGen-

Key figures

All Female Male
Number of individuals 2242 1039 1203
Unadjusted period prevalence (%) 0.51 0.41 0.60
Median age at first event (years) 65.26 64.60 65.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_CHRONICULCEROFSKIN and mortality.

Females

Parameter HR [95% CI] p-value
L12_CHRONICULCEROFSKIN 2.737 [2.44, 3.07] < 0.001
Birth year 0.997 [0.99, 1.0] 0.414

During the follow-up period (1.1.1998 — 31.12.2019), 4891 out of 9171 females with L12_CHRONICULCEROFSKIN died.

Males

Parameter HR [95% CI] p-value
L12_CHRONICULCEROFSKIN 3.37 [2.92, 3.89] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 3672 out of 7622 males with L12_CHRONICULCEROFSKIN died.

Mortality risk

Mortality risk for people of age

years, who have L12_CHRONICULCEROFSKIN.

N-year risk Females Males
1 0.291% 0.571%
5 1.719% 3.756%
10 4.085% 9.737%
15 7.977% 17.994%
20 13.621% 28.272%

Relationships between endpoints

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Index endpoint: L12_CHRONICULCEROFSKIN – Chronic ulcer of skin, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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