Hodgkins lymphoma: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
548 |
4. Check minimum number of eventsNone |
548 |
5. Include endpointsNone |
548 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L98
Name in latin
Granuloma pyogenicum
Similar endpoints
↥List of similar endpoints to
Pyogenic granuloma
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4805 | 2431 | 2340 |
| Only index persons | 4301 | 2212 | 2089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.38 | 42.80 | 41.78 |
| Only index persons | 43.15 | 42.91 | 43.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 294 | 232 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 53.75 | 48.58 | 60.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYOGENGRANUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.543 [1.27, 1.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 1977 females with L12_PYOGENGRANUL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.421 [1.16, 1.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1844 males with L12_PYOGENGRANUL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYOGENGRANUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | 0.302% |
| 5 | 1.04% | 1.5% |
| 10 | 2.355% | 4.318% |
| 15 | 4.488% | 8.409% |
| 20 | 7.648% | 14.355% |
Relationships between endpoints
↥Index endpoint: L12_PYOGENGRANUL – Pyogenic granuloma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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