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Factitial dermatitis

DOID EFO Endpoint Browser PheWeb

L12_FACTITIALDERMAT

neurotic excoriation: a condition in which patients produce skin lesions through repetitive, compulsive excoriation of their skin.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L98.1
  • Hospital discharge: ICD-9 — 6984A
  • Hospital discharge: ICD-8 — 6984
  • Cause of death: ICD-10 — L98.1
  • Cause of death: ICD-9 — 6984A
  • Cause of death: ICD-8 — 6984

2 out of 7 registries used, show all original rules.

172

4. Check minimum number of events

None

172

5. Include endpoints

None

172

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L98
Name in latin Dermatitis artificialis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1738 1165 556
Only index persons 1405 982 423
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.04 0.02
Median age at first event (years)
Whole population 54.96 55.45 53.93
Only index persons 53.35 54.22 51.35

-FinnGen-

Key figures

All Female Male
Number of individuals 164 114 50
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 47.26 46.40 49.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_FACTITIALDERMAT and mortality.

Females

Parameter HR [95% CI] p-value
L12_FACTITIALDERMAT 1.852 [1.48, 2.32] < 0.001
Birth year 0.996 [0.99, 1.0] 0.356

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 821 females with L12_FACTITIALDERMAT died.

Males

Parameter HR [95% CI] p-value
L12_FACTITIALDERMAT 2.697 [1.9, 3.82] < 0.001
Birth year 0.988 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 347 males with L12_FACTITIALDERMAT died.

Mortality risk

Mortality risk for people of age

years, who have L12_FACTITIALDERMAT.

N-year risk Females Males
1 0.189% 0.509%
5 1.244% 2.861%
10 2.935% 7.543%
15 5.525% 13.919%
20 9.486% 24.042%

Relationships between endpoints

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Index endpoint: L12_FACTITIALDERMAT – Factitial dermatitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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