decubitus ulcer: ['Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1917 |
4. Check minimum number of eventsNone |
1917 |
5. Include endpointsNone |
1917 |
6. Filter based on genotype QC (FinnGen only) |
1868 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Ulcus decubitale
Similar endpoints
↥List of similar endpoints to
Decubitus ulcer and pressure area
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29095 | 14548 | 14188 |
| Only index persons | 21152 | 10562 | 10590 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.42 | 0.40 |
| Only index persons | 0.40 | 0.39 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 74.87 | 79.07 | 70.62 |
| Only index persons | 75.04 | 79.60 | 70.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1868 | 724 | 1144 |
| Unadjusted period prevalence (%) | 0.46 | 0.28 | 0.57 |
| Median age at first event (years) | 72.34 | 72.39 | 72.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_DECUBITANSULCERANDPRESSURE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DECUBITANSULCERANDPRESSURE | 4.022 [3.42, 4.73] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.745 |
During the follow-up period (1.1.1998 — 31.12.2019), 6831 out of 9894 females with L12_DECUBITANSULCERANDPRESSURE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DECUBITANSULCERANDPRESSURE | 5.326 [4.4, 6.44] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 6314 out of 9835 males with L12_DECUBITANSULCERANDPRESSURE died.
Mortality risk
Mortality risk for people of age
years, who have L12_DECUBITANSULCERANDPRESSURE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.444% | 1.036% |
| 5 | 2.527% | 6.185% |
| 10 | 6.242% | 13.689% |
| 15 | 11.869% | 25.857% |
| 20 | 19.431% | 38.81% |
Relationships between endpoints
↥Index endpoint: L12_DECUBITANSULCERANDPRESSURE – Decubitus ulcer and pressure area
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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