pyoderma gangrenosum: ['An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
212 |
4. Check minimum number of eventsNone |
212 |
5. Include endpointsNone |
212 |
6. Filter based on genotype QC (FinnGen only) |
202 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Pyoderma gangraenosum
Similar endpoints
↥List of similar endpoints to
Pyoderma gangrenosum
based on the number of shared cases.
Similar with more cases:
- Pyoderma gangrenosum
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1335 | 828 | 497 |
| Only index persons | 1187 | 744 | 443 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 60.40 | 61.88 | 57.64 |
| Only index persons | 59.26 | 60.52 | 57.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 202 | 131 | 71 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 56.31 | 53.72 | 61.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYODERMAGANGRENOSUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYODERMAGANGRENOSUM | 3.197 [2.38, 4.29] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.172 |
During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 666 females with L12_PYODERMAGANGRENOSUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYODERMAGANGRENOSUM | 2.82 [2.05, 3.89] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 142 out of 421 males with L12_PYODERMAGANGRENOSUM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYODERMAGANGRENOSUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.377% | 0.652% |
| 5 | 1.696% | 3.451% |
| 10 | 4.702% | 8.603% |
| 15 | 8.592% | 15.171% |
| 20 | 15.107% | 25.253% |
Relationships between endpoints
↥Index endpoint: L12_PYODERMAGANGRENOSUM – Pyoderma gangrenosum
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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