dermatosis papulosa nigra: a condition of many small, benign skin lesions on the face, a condition generally presenting on dark-skinned individuals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
8082 |
4. Check minimum number of eventsNone |
8082 |
5. Include endpointsNone |
8082 |
6. Filter based on genotype QC (FinnGen only) |
7835 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Keratosis seborrhoica
Similar endpoints
↥List of similar endpoints to
Seborrhoeic keratosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 49790 | 30039 | 19626 |
| Only index persons | 48277 | 29332 | 18945 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.74 | 0.86 | 0.55 |
| Only index persons | 0.94 | 1.08 | 0.72 |
| Median age at first event (years) | |||
| Whole population | 68.02 | 67.80 | 68.34 |
| Only index persons | 67.81 | 67.58 | 68.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7835 | 4583 | 3252 |
| Unadjusted period prevalence (%) | 1.73 | 1.80 | 1.63 |
| Median age at first event (years) | 66.99 | 65.39 | 69.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_SEBORRKERAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_SEBORRKERAT | 0.877 [0.8, 0.96] | 0.004 |
| Birth year | 0.991 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 4512 out of 21592 females with L12_SEBORRKERAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_SEBORRKERAT | 0.905 [0.82, 1.0] | 0.058 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 3733 out of 14750 males with L12_SEBORRKERAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_SEBORRKERAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.067% | 0.192% |
| 5 | 0.425% | 0.993% |
| 10 | 1.095% | 2.52% |
| 15 | 2.198% | 5.123% |
| 20 | 3.916% | 8.665% |
Relationships between endpoints
↥Index endpoint: L12_SEBORRKERAT – Seborrhoeic keratosis
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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