No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4868 |
4. Check minimum number of eventsNone |
4868 |
5. Include endpointsNone |
4868 |
6. Filter based on genotype QC (FinnGen only) |
4705 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Ulcus membri inferioris non alibi classificatum
Similar endpoints
↥List of similar endpoints to
Ulcer of lower limb, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 42029 | 21214 | 20429 |
| Only index persons | 33056 | 16206 | 16850 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.59 | 0.61 | 0.57 |
| Only index persons | 0.62 | 0.60 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 72.21 | 76.30 | 68.02 |
| Only index persons | 71.89 | 76.27 | 67.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4705 | 1968 | 2737 |
| Unadjusted period prevalence (%) | 1.12 | 0.77 | 1.37 |
| Median age at first event (years) | 69.41 | 70.66 | 68.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ULCERLOWLIMB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ULCERLOWLIMB | 2.902 [2.55, 3.3] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.085 |
During the follow-up period (1.1.1998 — 31.12.2019), 7653 out of 14231 females with L12_ULCERLOWLIMB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ULCERLOWLIMB | 3.535 [3.05, 4.09] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 6963 out of 14586 males with L12_ULCERLOWLIMB died.
Mortality risk
Mortality risk for people of age
years, who have L12_ULCERLOWLIMB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.206% | 0.668% |
| 5 | 1.43% | 3.857% |
| 10 | 3.839% | 8.943% |
| 15 | 7.172% | 16.738% |
| 20 | 12.841% | 27.156% |
Relationships between endpoints
↥Index endpoint: L12_ULCERLOWLIMB – Ulcer of lower limb, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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