Tuberculosis, Cutaneous: Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.
Granulomatous disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_GRANULOMATOUSSKIN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
850 |
4. Check minimum number of eventsNone |
850 |
5. Include endpoints |
878 |
6. Filter based on genotype QC (FinnGen only) |
845 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Morbositates granulomatosae cutis et telae subcutaneae
Similar endpoints
↥List of similar endpoints to
Granulomatous disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6497 | 4475 | 1996 |
| Only index persons | 6066 | 4239 | 1827 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.06 |
| Only index persons | 0.13 | 0.16 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 48.67 | 49.20 | 47.60 |
| Only index persons | 48.68 | 49.22 | 47.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 845 | 633 | 212 |
| Unadjusted period prevalence (%) | 0.21 | 0.25 | 0.11 |
| Median age at first event (years) | 49.81 | 47.08 | 57.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANULOMATOUSSKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMATOUSSKIN | 1.145 [1.0, 1.32] | 0.059 |
| Birth year | 0.999 [0.99, 1.01] | 0.746 |
During the follow-up period (1.1.1998 — 31.12.2019), 354 out of 3770 females with L12_GRANULOMATOUSSKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMATOUSSKIN | 1.461 [1.22, 1.75] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 267 out of 1645 males with L12_GRANULOMATOUSSKIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANULOMATOUSSKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.267% |
| 5 | 0.787% | 1.629% |
| 10 | 1.85% | 4.028% |
| 15 | 3.655% | 7.592% |
| 20 | 6.152% | 13.196% |
Relationships between endpoints
↥Index endpoint: L12_GRANULOMATOUSSKIN – Granulomatous disorders of skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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