granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
472 |
4. Check minimum number of eventsNone |
472 |
5. Include endpointsNone |
472 |
6. Filter based on genotype QC (FinnGen only) |
456 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L92
Name in latin
Granuloma anulare
Similar endpoints
↥List of similar endpoints to
Granuloma annulare
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3343 | 2530 | 797 |
| Only index persons | 3180 | 2436 | 744 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.02 |
| Only index persons | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.83 | 50.97 | 50.58 |
| Only index persons | 51.04 | 51.08 | 50.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 456 | 365 | 91 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | 53.95 | 51.64 | 63.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANUANNU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANUANNU | 0.932 [0.77, 1.13] | 0.465 |
| Birth year | 0.995 [0.99, 1.0] | 0.213 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 2180 females with L12_GRANUANNU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANUANNU | 1.372 [1.06, 1.78] | 0.018 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 691 males with L12_GRANUANNU died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANUANNU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.277% |
| 5 | 0.604% | 1.707% |
| 10 | 1.334% | 4.135% |
| 15 | 2.672% | 7.778% |
| 20 | 4.563% | 13.472% |
Relationships between endpoints
↥Index endpoint: L12_GRANUANNU – Granuloma annulare
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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