granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
196 |
4. Check minimum number of eventsNone |
196 |
5. Include endpointsNone |
196 |
6. Filter based on genotype QC (FinnGen only) |
188 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L92
Name in latin
Necrobiosis lipoidica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Necrobiosis lipoidica, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1091 | 836 | 253 |
| Only index persons | 1019 | 789 | 230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.63 | 46.08 | 48.41 |
| Only index persons | 45.18 | 44.62 | 47.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 188 | 146 | 42 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 35.82 | 32.90 | 45.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_NECROLIPOIDIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 1.708 [1.34, 2.18] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 716 females with L12_NECROLIPOIDIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 2.888 [1.87, 4.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 221 males with L12_NECROLIPOIDIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_NECROLIPOIDIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.603% |
| 5 | 0.876% | 3.629% |
| 10 | 2.311% | 8.801% |
| 15 | 4.605% | 16.114% |
| 20 | 7.926% | 26.721% |
Relationships between endpoints
↥Index endpoint: L12_NECROLIPOIDIC – Necrobiosis lipoidica, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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