skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
440 |
4. Check minimum number of eventsNone |
440 |
5. Include endpointsNone |
440 |
6. Filter based on genotype QC (FinnGen only) |
429 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L85
Name in latin
Xerosis cutis
Similar endpoints
↥List of similar endpoints to
Xerosis cutis
based on the number of shared cases.
Similar with more cases:
- Other epidermal thickening
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2572 | 1334 | 1230 |
| Only index persons | 2357 | 1230 | 1127 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.29 | 67.94 | 68.83 |
| Only index persons | 68.76 | 68.34 | 69.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 429 | 210 | 219 |
| Unadjusted period prevalence (%) | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | 69.41 | 67.36 | 71.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_XEROSCUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_XEROSCUT | 1.673 [1.27, 2.2] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 875 females with L12_XEROSCUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_XEROSCUT | 2.043 [1.5, 2.79] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 820 males with L12_XEROSCUT died.
Mortality risk
Mortality risk for people of age
years, who have L12_XEROSCUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.113% | 0.411% |
| 5 | 0.808% | 2.582% |
| 10 | 2.019% | 6.221% |
| 15 | 3.996% | 12.021% |
| 20 | 7.158% | 19.296% |
Relationships between endpoints
↥Index endpoint: L12_XEROSCUT – Xerosis cutis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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