No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1406 |
4. Check minimum number of eventsNone |
1406 |
5. Include endpoints |
1465 |
6. Filter based on genotype QC (FinnGen only) |
1405 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Alia crassificatio epidermidis
Similar endpoints
↥List of similar endpoints to
Other epidermal thickening
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11143 | 5842 | 5246 |
| Only index persons | 10074 | 5399 | 4675 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.17 | 0.15 |
| Only index persons | 0.19 | 0.20 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 54.82 | 55.17 | 54.43 |
| Only index persons | 54.88 | 55.18 | 54.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1405 | 760 | 645 |
| Unadjusted period prevalence (%) | 0.31 | 0.30 | 0.32 |
| Median age at first event (years) | 58.34 | 55.38 | 61.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_EPIDERMALTHICKOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_EPIDERMALTHICKOTH | 1.335 [1.16, 1.53] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 4472 females with L12_EPIDERMALTHICKOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_EPIDERMALTHICKOTH | 1.552 [1.33, 1.81] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 899 out of 3883 males with L12_EPIDERMALTHICKOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_EPIDERMALTHICKOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.271% |
| 5 | 0.917% | 1.62% |
| 10 | 2.242% | 3.923% |
| 15 | 4.196% | 7.346% |
| 20 | 7.089% | 12.323% |
Relationships between endpoints
↥Index endpoint: L12_EPIDERMALTHICKOTH – Other epidermal thickening
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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