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Other and unspecified epidermal thickening

EFO MESH Endpoint Browser PheWeb

L12_EPIDERMTHICKNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L85.80, L85.81, L85.89, L85.9
  • Hospital discharge: ICD-9 — 7018G
  • Hospital discharge: ICD-8 — 70119
  • Cause of death: ICD-10 — L85.80, L85.81, L85.89, L85.9
  • Cause of death: ICD-9 — 7018G
  • Cause of death: ICD-8 — 70119

2 out of 7 registries used, show all original rules.

904

4. Check minimum number of events

None

904

5. Include endpoints

None

904

6. Filter based on genotype QC (FinnGen only)

861

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7347 3872 3440
Only index persons 6683 3612 3071
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.10
Only index persons 0.13 0.13 0.12
Median age at first event (years)
Whole population 51.27 51.51 50.95
Only index persons 51.20 51.44 50.92

-FinnGen-

Key figures

All Female Male
Number of individuals 861 482 379
Unadjusted period prevalence (%) 0.19 0.19 0.19
Median age at first event (years) 54.63 51.48 58.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_EPIDERMTHICKNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_EPIDERMTHICKNAS 1.228 [1.06, 1.42] 0.007
Birth year 0.994 [0.99, 1.0] 0.146

During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3191 females with L12_EPIDERMTHICKNAS died.

Males

Parameter HR [95% CI] p-value
L12_EPIDERMTHICKNAS 1.233 [1.05, 1.44] 0.009
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 555 out of 2752 males with L12_EPIDERMTHICKNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_EPIDERMTHICKNAS.

N-year risk Females Males
1 0.112% 0.254%
5 0.796% 1.429%
10 1.809% 3.74%
15 3.451% 7.347%
20 6.151% 12.246%

Relationships between endpoints

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Index endpoint: L12_EPIDERMTHICKNAS – Other and unspecified epidermal thickening

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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