skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Acquired keratosis [keratoderma] palmaris et plantaris
DOID EFO Endpoint Browser PheWeb
L12_ACQKERAT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
142 |
4. Check minimum number of eventsNone |
142 |
5. Include endpointsNone |
142 |
6. Filter based on genotype QC (FinnGen only) |
137 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L85
Name in latin
Keratosis (keratoderma) palmaris et plantaris acquisita
Similar endpoints
↥List of similar endpoints to
Acquired keratosis [keratoderma] palmaris et plantaris
based on the number of shared cases.
Similar with more cases:
- Other epidermal thickening
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1124 | 601 | 516 |
| Only index persons | 982 | 536 | 446 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.60 | 57.17 | 51.70 |
| Only index persons | 54.36 | 56.87 | 51.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137 | 74 | 63 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 55.51 | 56.94 | 53.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACQKERAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACQKERAT | 1.483 [1.05, 2.09] | 0.025 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 400 females with L12_ACQKERAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACQKERAT | 1.494 [1.12, 2.0] | 0.007 |
| Birth year | 0.987 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 297 males with L12_ACQKERAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACQKERAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.303% |
| 5 | 0.719% | 1.604% |
| 10 | 1.966% | 4.021% |
| 15 | 3.781% | 7.835% |
| 20 | 6.415% | 13.288% |
Relationships between endpoints
↥Index endpoint: L12_ACQKERAT – Acquired keratosis [keratoderma] palmaris et plantaris
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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