Vitiligo: Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
359 |
4. Check minimum number of eventsNone |
359 |
5. Include endpointsNone |
359 |
6. Filter based on genotype QC (FinnGen only) |
339 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Vitiligo
Similar endpoints
↥List of similar endpoints to
Vitiligo
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3372 | 1868 | 1488 |
| Only index persons | 3076 | 1720 | 1356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 36.14 | 37.31 | 34.62 |
| Only index persons | 36.81 | 38.02 | 35.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 339 | 205 | 134 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.07 |
| Median age at first event (years) | 46.03 | 44.98 | 47.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_VITILIGO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VITILIGO | 1.203 [0.93, 1.55] | 0.156 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1518 females with L12_VITILIGO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VITILIGO | 1.183 [0.94, 1.49] | 0.157 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 1189 males with L12_VITILIGO died.
Mortality risk
Mortality risk for people of age
years, who have L12_VITILIGO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.247% |
| 5 | 0.704% | 1.539% |
| 10 | 1.552% | 3.646% |
| 15 | 3.01% | 6.626% |
| 20 | 5.436% | 10.822% |
Relationships between endpoints
↥Index endpoint: L12_VITILIGO – Vitiligo
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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