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Corns and callosities

EFO MESH Endpoint Browser PheWeb

L12_CORNSANDCALLOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L84
  • Hospital discharge: ICD-9 — 700
  • Hospital discharge: ICD-8 — 700
  • Cause of death: ICD-10 — L84
  • Cause of death: ICD-9 — 700
  • Cause of death: ICD-8 — 700

2 out of 7 registries used, show all original rules.

2426

4. Check minimum number of events

None

2426

5. Include endpoints

None

2426

6. Filter based on genotype QC (FinnGen only)

2349

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L80-L99
Name in latin Clavi et callositates

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17939 10071 7750
Only index persons 15799 8959 6840
Unadjusted period prevalence (%)
Whole population 0.26 0.29 0.22
Only index persons 0.30 0.33 0.26
Median age at first event (years)
Whole population 53.72 54.88 52.21
Only index persons 52.65 53.77 51.18

-FinnGen-

Key figures

All Female Male
Number of individuals 2349 1344 1005
Unadjusted period prevalence (%) 0.52 0.53 0.50
Median age at first event (years) 52.57 51.12 54.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_CORNSANDCALLOS and mortality.

Females

Parameter HR [95% CI] p-value
L12_CORNSANDCALLOS 1.576 [1.42, 1.75] < 0.001
Birth year 0.995 [0.99, 1.0] 0.27

During the follow-up period (1.1.1998 — 31.12.2019), 1470 out of 6613 females with L12_CORNSANDCALLOS died.

Males

Parameter HR [95% CI] p-value
L12_CORNSANDCALLOS 1.885 [1.66, 2.13] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1422 out of 5077 males with L12_CORNSANDCALLOS died.

Mortality risk

Mortality risk for people of age

years, who have L12_CORNSANDCALLOS.

N-year risk Females Males
1 0.15% 0.344%
5 0.782% 1.881%
10 2.251% 4.94%
15 4.545% 9.294%
20 8.205% 15.907%

Relationships between endpoints

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Index endpoint: L12_CORNSANDCALLOS – Corns and callosities

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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