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Scar conditions and fibrosis of skin

DOID EFO Endpoint Browser PheWeb

L12_SCARCONDITIONS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L90.5
  • Hospital discharge: ICD-9 — 7092
  • Hospital discharge: ICD-8 — 7090[6-7]
  • Cause of death: ICD-10 — L90.5
  • Cause of death: ICD-9 — 7092
  • Cause of death: ICD-8 — 7090[6-7]

2 out of 7 registries used, show all original rules.

1386

4. Check minimum number of events

None

1386

5. Include endpoints

None

1386

6. Filter based on genotype QC (FinnGen only)

1332

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L90
Name in latin Conditiones cicatricales et fibroses cutis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10628 7098 3457
Only index persons 9929 6769 3160
Unadjusted period prevalence (%)
Whole population 0.17 0.20 0.10
Only index persons 0.21 0.25 0.12
Median age at first event (years)
Whole population 39.03 40.91 35.05
Only index persons 38.45 40.47 34.13

-FinnGen-

Key figures

All Female Male
Number of individuals 1332 1004 328
Unadjusted period prevalence (%) 0.34 0.39 0.16
Median age at first event (years) 45.84 45.81 45.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_SCARCONDITIONS and mortality.

Females

Parameter HR [95% CI] p-value
L12_SCARCONDITIONS 1.162 [1.0, 1.34] 0.043
Birth year 0.999 [0.99, 1.01] 0.85

During the follow-up period (1.1.1998 — 31.12.2019), 317 out of 4944 females with L12_SCARCONDITIONS died.

Males

Parameter HR [95% CI] p-value
L12_SCARCONDITIONS 1.13 [0.96, 1.34] 0.151
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 2379 males with L12_SCARCONDITIONS died.

Mortality risk

Mortality risk for people of age

years, who have L12_SCARCONDITIONS.

N-year risk Females Males
1 0.171% 0.243%
5 0.873% 1.446%
10 2.118% 3.502%
15 3.909% 6.488%
20 6.892% 10.721%

Relationships between endpoints

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Index endpoint: L12_SCARCONDITIONS – Scar conditions and fibrosis of skin

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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