No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3361 |
4. Check minimum number of eventsNone |
3361 |
5. Include endpointsNone |
3361 |
6. Filter based on genotype QC (FinnGen only) |
3262 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L90
Name in latin
Lichen sclerosus et atrophicus
Similar endpoints
↥List of similar endpoints to
Lichen sclerosus et atrophicus
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21817 | 18224 | 3552 |
| Only index persons | 21007 | 17541 | 3466 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.52 | 0.10 |
| Only index persons | 0.56 | 0.64 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 60.38 | 64.39 | 39.87 |
| Only index persons | 60.31 | 64.36 | 39.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3262 | 2842 | 420 |
| Unadjusted period prevalence (%) | 1.00 | 1.12 | 0.21 |
| Median age at first event (years) | 62.23 | 63.63 | 52.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_LICHENSCLERATROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSCLERATROPH | 0.833 [0.75, 0.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 13288 females with L12_LICHENSCLERATROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSCLERATROPH | 0.786 [0.64, 0.97] | 0.023 |
| Birth year | 0.992 [0.98, 1.0] | 0.134 |
During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 2735 males with L12_LICHENSCLERATROPH died.
Mortality risk
Mortality risk for people of age
years, who have L12_LICHENSCLERATROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.13% |
| 5 | 0.44% | 0.996% |
| 10 | 0.985% | 2.672% |
| 15 | 1.926% | 5.039% |
| 20 | 3.252% | 8.678% |
Relationships between endpoints
↥Index endpoint: L12_LICHENSCLERATROPH – Lichen sclerosus et atrophicus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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