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Striae atrophicae

DOID EFO Endpoint Browser PheWeb

L12_STRIAEATROPHICAE

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L90.6
  • Hospital discharge: ICD-9 — 7013X
  • Hospital discharge: ICD-8 — 70120
  • Cause of death: ICD-10 — L90.6
  • Cause of death: ICD-9 — 7013X
  • Cause of death: ICD-8 — 70120

2 out of 7 registries used, show all original rules.

355

4. Check minimum number of events

None

355

5. Include endpoints

None

355

6. Filter based on genotype QC (FinnGen only)

335

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L90
Name in latin Striae atrophicae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2553 1773 764
Only index persons 2451 1722 729
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 34.96 37.84 28.31
Only index persons 35.09 37.92 28.41

-FinnGen-

Key figures

All Female Male
Number of individuals 335 268 67
Unadjusted period prevalence (%) 0.09 0.11 0.03
Median age at first event (years) 43.13 42.91 44.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_STRIAEATROPHICAE and mortality.

Females

Parameter HR [95% CI] p-value
L12_STRIAEATROPHICAE 1.328 [1.01, 1.75] 0.045
Birth year 0.996 [0.99, 1.0] 0.317

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 1519 females with L12_STRIAEATROPHICAE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_STRIAEATROPHICAE.

N-year risk Females Males
1 0.137% No data
5 0.764% No data
10 1.961% No data
15 3.999% No data
20 7.169% No data

Relationships between endpoints

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Index endpoint: L12_STRIAEATROPHICAE – Striae atrophicae

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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