thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
37127 |
4. Check minimum number of eventsNone |
37127 |
5. Include endpoints
|
70653 |
6. Filter based on genotype QC (FinnGen only) |
68103 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of the thyroid gland
based on the number of shared cases.
Similar with more cases:
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 566613 | 446419 | 116533 |
| Only index persons | 517238 | 412052 | 105186 |
| Unadjusted period prevalence (%) | |||
| Whole population | 10.77 | 12.79 | 3.26 |
| Only index persons | 12.88 | 15.15 | 4.02 |
| Median age at first event (years) | |||
| Whole population | 54.73 | 53.73 | 58.77 |
| Only index persons | 53.71 | 52.65 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 68103 | 54021 | 14082 |
| Unadjusted period prevalence (%) | 18.29 | 21.22 | 7.07 |
| Median age at first event (years) | 51.98 | 50.01 | 59.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROID | 0.976 [0.9, 1.05] | 0.526 |
| Birth year | 0.998 [0.99, 1.01] | 0.568 |
During the follow-up period (1.1.1998 — 31.12.2019), 43600 out of 324502 females with E4_THYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROID | 1.205 [1.1, 1.32] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 21205 out of 91502 males with E4_THYROID died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.186% |
| 5 | 0.464% | 1.227% |
| 10 | 1.35% | 3.409% |
| 15 | 2.653% | 6.383% |
| 20 | 4.816% | 11.129% |
Relationships between endpoints
↥Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 126
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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