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This is a non-core endpoint: only basic statistics are computed.

Subclinical iodine-deficiency hypothyroidism

E4_IODHYPSUB

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E02
  • Cause of death: ICD-10 E02

2 out of 7 registries used, show all original rules.

43

4. Check minimum number of events

None

43

5. Include endpoints

None

43

6. Filter based on genotype QC (FinnGen only)

43

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E00-E07
Name in latin Hypothyreosis subclinica ex deficientia iodi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 326 238 86
Only index persons 302 223 79
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 64.28 63.43 66.30
Only index persons 62.37 60.81 66.78

-FinnGen-

Key figures

All Female Male
Number of individuals 43 27 16
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 59.60 58.94 60.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint E4_IODHYPSUB and mortality.

Females

Parameter HR [95% CI] p-value
E4_IODHYPSUB 1.248 [0.81, 1.93] 0.321
Birth year 0.995 [0.99, 1.0] 0.261

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 212 females with E4_IODHYPSUB died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_IODHYPSUB.

N-year risk Females Males
1 0.133% No data
5 0.77% No data
10 1.857% No data
15 3.379% No data
20 5.813% No data

Relationships between endpoints

Index endpoint: E4_IODHYPSUB – Subclinical iodine-deficiency hypothyroidism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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