This is a non-core endpoint: only basic statistics are computed.
Subclinical iodine-deficiency hypothyroidism
E4_IODHYPSUB
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
43 |
4. Check minimum number of eventsNone |
43 |
5. Include endpointsNone |
43 |
6. Filter based on genotype QC (FinnGen only) |
43 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E00-E07
Name in latin
Hypothyreosis subclinica ex deficientia iodi
Similar endpoints
↥List of similar endpoints to
Subclinical iodine-deficiency hypothyroidism
based on the number of shared cases.
Similar with more cases:
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 326 | 238 | 86 |
| Only index persons | 302 | 223 | 79 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.28 | 63.43 | 66.30 |
| Only index persons | 62.37 | 60.81 | 66.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 43 | 27 | 16 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 59.60 | 58.94 | 60.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_IODHYPSUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IODHYPSUB | 1.248 [0.81, 1.93] | 0.321 |
| Birth year | 0.995 [0.99, 1.0] | 0.261 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 212 females with E4_IODHYPSUB died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_IODHYPSUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | No data |
| 5 | 0.77% | No data |
| 10 | 1.857% | No data |
| 15 | 3.379% | No data |
| 20 | 5.813% | No data |
Relationships between endpoints
↥Index endpoint: E4_IODHYPSUB – Subclinical iodine-deficiency hypothyroidism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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