hypothyroidism: Abnormally low levels of thyroid hormone.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
193 |
4. Check minimum number of eventsNone |
193 |
5. Include endpointsNone |
193 |
6. Filter based on genotype QC (FinnGen only) |
185 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Hypothyreosis postinfectiosa
Similar endpoints
↥List of similar endpoints to
Postinfectious hypothyroidism
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2062 | 1681 | 349 |
| Only index persons | 1434 | 1198 | 236 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.61 | 56.08 | 52.28 |
| Only index persons | 48.62 | 49.33 | 45.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 185 | 157 | 28 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 40.48 | 39.23 | 47.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHYPOSTINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYPOSTINF | 1.889 [1.3, 2.75] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.278 |
During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 430 females with E4_HYTHYPOSTINF died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYTHYPOSTINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | No data |
| 5 | 1.234% | No data |
| 10 | 2.848% | No data |
| 15 | 5.051% | No data |
| 20 | 9.149% | No data |
Relationships between endpoints
↥Index endpoint: E4_HYTHYPOSTINF – Postinfectious hypothyroidism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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