≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO Endpoint Browser PheWeb

E4_CONGEIOD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E00, E03.0, E03.1
  • Hospital discharge: ICD-9 — 243
  • Hospital discharge: ICD-8 — 243
  • Cause of death: ICD-10 — E00, E03.0, E03.1
  • Cause of death: ICD-9 — 243
  • Cause of death: ICD-8 — 243

2 out of 7 registries used, show all original rules.

1047

4. Check minimum number of events

None

1047

5. Include endpoints

None

1047

6. Filter based on genotype QC (FinnGen only)

1006

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11024 8810 2178
Only index persons 10110 8174 1936
Unadjusted period prevalence (%)
Whole population 0.21 0.25 0.06
Only index persons 0.26 0.30 0.07
Median age at first event (years)
Whole population 67.75 68.82 63.38
Only index persons 67.54 68.52 63.45

-FinnGen-

Key figures

All Female Male
Number of individuals 1006 806 200
Unadjusted period prevalence (%) 0.27 0.32 0.10
Median age at first event (years) 61.05 59.63 66.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CONGEIOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_CONGEIOD 1.653 [1.47, 1.86] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 2652 out of 8009 females with E4_CONGEIOD died.

Males

Parameter HR [95% CI] p-value
E4_CONGEIOD 2.094 [1.67, 2.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 700 out of 1891 males with E4_CONGEIOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_CONGEIOD.

N-year risk Females Males
1 0.098% 0.386%
5 0.745% 2.472%
10 1.882% 5.762%
15 3.749% 10.868%
20 6.505% 17.926%

Relationships between endpoints

↥

Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data