Acute thyroiditis

E4_THYROIDITACU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E06.0
  • Hospital discharge: ICD-9 2450
  • Cause of death: ICD-10 E06.0
  • Cause of death: ICD-9 2450

2 out of 7 registries used, show all original rules.

135

4. Check minimum number of events

None

135

5. Include endpoints

None

135

6. Filter based on genotype QC (FinnGen only)

130

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1138 842 289
Only index persons 1081 812 269
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.03 0.01
Median age at first event (years)
Whole population 46.43 45.51 49.44
Only index persons 45.78 44.95 48.29

-FinnGen-

Key figures

All Female Male
Number of individuals 130 98 32
Unadjusted period prevalence (%) 0.03 0.04 0.02
Median age at first event (years) 47.65 46.30 51.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint E4_THYROIDITACU and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITACU 1.181 [0.92, 1.52] 0.199
Birth year 0.999 [0.99, 1.01] 0.739

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITACU.

N-year risk Females Males
1 0.117% No data
5 0.776% No data
10 1.927% No data
15 3.803% No data
20 6.664% No data

Relationships between endpoints

Index endpoint: E4_THYROIDITACU – Acute thyroiditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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