No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2521 |
6. Filter based on genotype QC (FinnGen only) |
2436 |
Control definitions (FinnGen only)
Control exclude
THYROID_DISORDER_IBD
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Thyroiditis
based on the number of shared cases.
Similar with more cases:
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19571 | 15459 | 3979 |
| Only index persons | 17896 | 14316 | 3580 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.44 | 0.11 |
| Only index persons | 0.45 | 0.53 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 45.67 | 45.04 | 48.17 |
| Only index persons | 44.76 | 44.12 | 47.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2436 | 2005 | 431 |
| Unadjusted period prevalence (%) | 0.69 | 0.79 | 0.22 |
| Median age at first event (years) | 45.70 | 44.74 | 50.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint THYROIDITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THYROIDITIS | 1.008 [0.89, 1.14] | 0.906 |
| Birth year | 0.996 [0.99, 1.01] | 0.422 |
During the follow-up period (1.1.1998 — 31.12.2019), 612 out of 10163 females with THYROIDITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THYROIDITIS | 0.815 [0.7, 0.94] | 0.007 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 242 out of 2542 males with THYROIDITIS died.
Mortality risk
Mortality risk for people of age
years, who have THYROIDITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.169% |
| 5 | 0.579% | 1.044% |
| 10 | 1.518% | 2.768% |
| 15 | 2.872% | 5.227% |
| 20 | 5.1% | 8.575% |
Relationships between endpoints
↥Index endpoint: THYROIDITIS – Thyroiditis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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