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Thyroiditis, unspecified

DOID EFO Endpoint Browser PheWeb

E4_THYROIDITNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.9
  • Hospital discharge: ICD-9 — 2459
  • Hospital discharge: ICD-8 — 24509
  • Cause of death: ICD-10 — E06.9
  • Cause of death: ICD-9 — 2459
  • Cause of death: ICD-8 — 24509

2 out of 7 registries used, show all original rules.

528

4. Check minimum number of events

None

528

5. Include endpoints

None

528

6. Filter based on genotype QC (FinnGen only)

504

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis non specificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4136 3328 780
Only index persons 3597 2934 663
Unadjusted period prevalence (%)
Whole population 0.08 0.10 0.02
Only index persons 0.09 0.11 0.03
Median age at first event (years)
Whole population 43.92 43.41 45.87
Only index persons 42.03 41.65 43.74

-FinnGen-

Key figures

All Female Male
Number of individuals 504 418 86
Unadjusted period prevalence (%) 0.14 0.16 0.04
Median age at first event (years) 40.80 40.70 41.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_THYROIDITNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITNAS 1.07 [0.88, 1.3] 0.502
Birth year 0.992 [0.98, 1.0] 0.081

During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 1872 females with E4_THYROIDITNAS died.

Males

Parameter HR [95% CI] p-value
E4_THYROIDITNAS 1.031 [0.79, 1.35] 0.827
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 435 males with E4_THYROIDITNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITNAS.

N-year risk Females Males
1 0.1% 0.199%
5 0.55% 1.133%
10 1.31% 2.965%
15 2.674% 5.73%
20 4.741% 9.773%

Relationships between endpoints

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Index endpoint: E4_THYROIDITNAS – Thyroiditis, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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