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Autoimmune thyroiditis

DOID EFO Endpoint Browser PheWeb

E4_THYROIDITAUTOIM

autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.3
  • Hospital discharge: ICD-9 — 2452
  • Cause of death: ICD-10 — E06.3
  • Cause of death: ICD-9 — 2452

2 out of 7 registries used, show all original rules.

626

4. Check minimum number of events

None

626

5. Include endpoints

None

626

6. Filter based on genotype QC (FinnGen only)

612

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis autoimmunis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5469 4605 837
Only index persons 5134 4357 777
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.02
Only index persons 0.14 0.16 0.03
Median age at first event (years)
Whole population 38.53 38.87 36.49
Only index persons 38.30 38.64 36.40

-FinnGen-

Key figures

All Female Male
Number of individuals 612 532 80
Unadjusted period prevalence (%) 0.19 0.21 0.04
Median age at first event (years) 44.55 43.70 50.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_THYROIDITAUTOIM and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITAUTOIM 1.029 [0.88, 1.2] 0.713
Birth year 0.996 [0.99, 1.0] 0.367

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 3629 females with E4_THYROIDITAUTOIM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITAUTOIM.

N-year risk Females Males
1 0.083% No data
5 0.497% No data
10 1.444% No data
15 2.964% No data
20 5.351% No data

Relationships between endpoints

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Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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