Hypothyroidism, autoimmune, DX-based

E4_HYTHY_AI_DX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • E4_THYROIDITAUTOIM
626

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E03.80
  • Cause of death: ICD-10 E03.80

2 out of 7 registries used, show all original rules.

125

4. Check minimum number of events

None

125

5. Include endpoints

None

125

6. Filter based on genotype QC (FinnGen only)

123

Control definitions (FinnGen only)

Control conditions not E4_THYROIDITAUTOIM

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1013 858 154
Only index persons 972 826 146
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.00
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 25.77 27.49 15.90
Only index persons 26.47 28.23 16.49

-FinnGen-

Key figures

All Female Male
Number of individuals 123 114 9
Unadjusted period prevalence (%) 0.04 0.04 0.00
Median age at first event (years) 41.21 40.90 45.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint E4_HYTHY_AI_DX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYTHY_AI_DX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_HYTHY_AI_DX – Hypothyroidism, autoimmune, DX-based

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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