subacute thyroiditis: Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1219 |
4. Check minimum number of eventsNone |
1219 |
5. Include endpointsNone |
1219 |
6. Filter based on genotype QC (FinnGen only) |
1175 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF10
Parent code in ICD-10
E06
Name in latin
Thyreoiditis subacuta
Similar endpoints
↥List of similar endpoints to
Subacute thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8817 | 6740 | 2008 |
| Only index persons | 8221 | 6380 | 1841 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.06 |
| Only index persons | 0.20 | 0.23 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 48.24 | 47.71 | 50.24 |
| Only index persons | 47.78 | 47.28 | 49.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1175 | 963 | 212 |
| Unadjusted period prevalence (%) | 0.33 | 0.38 | 0.11 |
| Median age at first event (years) | 47.86 | 47.57 | 49.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITSUBAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITSUBAC | 0.833 [0.71, 0.98] | 0.025 |
| Birth year | 0.993 [0.98, 1.0] | 0.139 |
During the follow-up period (1.1.1998 — 31.12.2019), 208 out of 4418 females with E4_THYROIDITSUBAC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITSUBAC | 0.597 [0.48, 0.74] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1239 males with E4_THYROIDITSUBAC died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDITSUBAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.066% | 0.092% |
| 5 | 0.527% | 0.625% |
| 10 | 1.263% | 1.65% |
| 15 | 2.331% | 3.15% |
| 20 | 4.065% | 5.585% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITSUBAC – Subacute thyroiditis
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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